Take Control of
Hot Flashes

Cryo-1 helps interrupt a hot flash in about 60-90 seconds - without hormones, drugs, or waiting it out.
Based on 29 reviews

Cryo-1

Shop Now
  • Image

    Every Woman going through Perimenopause should have a tool like this.
    Image

    Kristen C.
How to use Cryo-1 during a

Hot Flash

Many women users report significant relief from Hot Flashes, with some experiencing complete interruption after just 60 seconds.

Turn it on when a hot flash starts
Turn the device on maximum cold. The device will reach ideal operating temperature in 60 seconds (you can use it right away, it just cools a little slower when hand held).
Hold it comfortably in your palm
Most women feel relief within 60–90 seconds.
Stay in control
Use as often as needed throughout the day or night.

Customers are Saying
Loading videos...

How Cryo-1 Helps Hot-Flashes

Problem

Hot Flashes Can Feel Sudden and Overwhelming

Hormonal changes can make your body’s temperature control system more sensitive, even during your 30s and 40s.

Your heart races. Heat surges. Sometimes chills follow right after.

These temperature swings can interrupt sleep, focus, confidence, and daily life.
Image

During a hot flash

Your Body Is Reacting Like It’s Overheating
  • Blood vessels open to release heat
  • Heart rate increases
  • Sweating and flushing begin

Afterward, the body can swing too far the other way, causing chills or shivering. It can feel unpredictable because your internal thermostat is overreacting.
Image

Solution

Palm Cooling + Warming Helps Calm the Response

The palms contain specialized blood vessels that help regulate body temperature.

Cryo-1 uses controlled cooling or warming to help your body offload heat or restore warmth faster. It will help you:
  • Cool during heat surges
  • Warm during chills
  • Help your nervous system settle

The result is faster relief & better temperature regulation.
Image

Peer reviewed Science

Research shows that core temperature regulation can help relieve peri-menopausal symptoms.

Freedman (2001)
Clinical Trial Confirms Palm Cooling Relief

A 2015 study supported the link between reduced core temperature and fewer or milder flashes.

Cryo-1 applies this same proven principle but uses palm cooling - the Stanford-validated method that directly cools the blood and rapidly stabilizes core temperature.

In Cryomedics’ own user trials, 100% of women reported noticeable relief, with most feeling cooler within 60 seconds

Read the study
Freedman (2001)
Menopause Narrows the Thermal Comfort Zone

Physiological studies suggest palm cooling works by widening the narrowed “thermoneutral zone” caused by low estrogen, allowing excess heat to offload through the palms.

Research by Freedman and colleagues has shown that postmenopausal women have a much narrower thermoneutral zone, meaning very slight changes in core temperature can set off this hypothalamic response

Read the study
Freedman (2001)
Palm Cooling Stabilizes the Body’s Thermostat

Laboratory research outside of Freedman’s early studies shows that the hypothalamus acts like a thermostat that can become unstable in menopause, causing sudden bursts of heat release.

Palm cooling removes heat directly from the bloodstream, helping to stabilize this thermostat. As a result, women experience fewer episodes of rapid overheating and the uncomfortable waves of sweating that follow

Read the study
Freedman (2001)
Peripheral Warming Relieves Menopausal Chills

Early human and physiology data show that during menopause, drops in estrogen heighten sensitivity to cold and trigger chills.

Though direct trials of warming interventions are still emerging, this review notes that warming peripheral skin - especially areas rich in AVAs (arteriovenous anastomoses) like the palms - can help restore thermal comfort by improving circulation and reducing cold sensations.

Many women reported relief from cold sweats and shivering when warming strategies were used.

Read the study

Listen To An Expert

The Palm Cooling Advantage Explained

Here's neuroscientist Andrew Huberman breaking down why palm cooling works at a physiological level and the extraordinary results it offers.

If you want the science, straight from the lab, hit the play button.
Cryo-1

Cryo-1

$149
Pay using HSA/FSA with

Checkout With Your HSA/FSA

Maximize your pre-tax HSA/FSA dollars.

  1. Checkout as a guest.

  2. Select the Flex | Pay with HSA/FSA option.

  3. Enter your HSA/FSA card details & enjoy your savings!
Accelerate Recovery. Reduce Heat Related Distress.

Cryo-1 is a handheld cooling + warming device designed to help your body regulate temperature and recover faster in real time. Use it in your palms to cool your core, or on the side of your neck when you need to calm your body fast.
Key Features
Image
About the size of a small water bottle.
Image
Cools & Warms. Battery life up to 4hrs.
Image
12 month warranty, 30 day trial period.
Image
No water, no ice needed.
Specifications & User Manual
Temperature Modes

Cooling: 12, 14, 16 °C (54, 57, 61 °F)
Warming: 35, 39, 43 °C (95, 102, 109 °F)

Battery Life

Cooling: 1 to 3 hours per charge (depending on selected intensity)
Warming: 3 to 4 hours per charge (depending on selected intensity)

Operating temperature

Best used in environment under 80°F/26°C. Expect slower cooling at warmer temps.

Cycle time

Auto off after 20mins

Dimensions

6.28 in (H) × 2.83 in (D) × 2.44 in (W)
160 mm (H) × 72 mm (D) × 62 mm (W)

Weight

13.8 oz (390 g)

Power

Rechargeable lithium-ion battery (USB-C charging). Approx 4hrs full recharge time.

User Manual

Click to download.
Warranty & Returns
Warranty

Cryo-1 comes with a full 12-month manufacturer warranty. If it fails, we'll replace it at our cost.

Returns

We offer a 30-day return period. If you’re not satisfied, you may return your Cryo-1 in its original packaging for a refund.
Paying with FSA/HSA cards

At checkout you may pay with your FSA/HSA card. Just choose FSA/HSA as the payment method.

FDA-Registered Manufacturer
FDA-Listed Class I Therapeutic Device

  • Cryomedics LLC is officially registered with the U.S. Food and Drug Administration as a medical device establishment.
  • Cryo-1 is listed as a Class I device under FDA regulations.
  • Most HSA/FSA plans recognize Class I therapeutic devices as eligible medical expenses. Check with your plan administrator to confirm coverage.

Frequently asked Questions
How long does the battery last?

Cryo-1 delivers extended use on a single charge. Battery will last longer when used on lower power settings.

  • Cooling runtime: 1 to 3 hours
  • Warming runtime: 3 to 4 hours
How do I recharge Cryo-1?

Cryo-1 recharges via USB-C in about 3.5 to 4 hours using a standard 5V/3A power source.
Does Cryo-1 require ice or water?

No. Cryo-1 uses built-in battery powered cooling modules - no ice, water, or prep required.
Is Cryo-1 noisy?

Not at all. Cryo-1 operates at 47 dB, similar to a very quiet computer fan.

More FAQ's