Take Control of Hot Flashes

Cryo-1 helps interrupt a hot flash in about 60-90 seconds - without hormones, drugs, or waiting it out.

How it Works Buy Cryo-1
Every Woman going through Perimenopause should have a tool like this.

Kristen C.

Hot Flashes
Night Sweats
Sleep Disruption
Pickleball
Golf
Heat Stress
Running
Tennis
Anxiety Relief
Temperature Swings
Menopause
Perimenopause
Walking
Yoga
Strength Training
Hot Flashes
Night Sweats
Sleep Disruption
Pickleball
Golf
Heat Stress
Running
Tennis
Anxiety Relief
Temperature Swings
Menopause
Perimenopause
Walking
Yoga
Strength Training
Long Battery Life
Portable
Quiet
Lightweight
Handheld
Rapid Cooling
Rapid Warming
Easy to Use
No Ice Needed
USB-C Charging
Durable
Discreet
Use Anywhere
Long Battery Life
Portable
Quiet
Lightweight
Handheld
Rapid Cooling
Rapid Warming
Easy to Use
No Ice Needed
USB-C Charging
Durable
Discreet
Use Anywhere
SIMPLE. DISCREET. ON YOUR TERMS.

How to Use Cryo‑1 During a Hot Flash

1. Turn it on when a hot flash starts
Turn the device on maximum cold. The device will reach ideal operating temperature in 60 seconds (you can use it right away, it just cools a little slower when hand held).

2. Hold it comfortably in your palm
Most women feel relief within 60–90 seconds.

3. Stay in control
Use as often as needed throughout the day or night.

REAL USERS REPORT

Relief You Can Feel

Women using Cryo‑1 commonly report:

  • Faster relief when hot flashes start
  • Reduced intensity of heat and chills
  • Less anxiety during episodes
  • Better sleep and fewer nighttime disruptions

Many women in our testing reported significant relief, with some experiencing complete interruption of hot flashes when used early.

Results vary, but the goal is simple: help you feel better, faster.

Woman lying on a bed in a dimly lit room
WHAT YOU’RE FEELING IS REAL

Hot Flashes Aren’t Random - & They’re Not Your Fault

Hot flashes can feel sudden, overwhelming, and out of your control.

Your heart races. Heat surges. Anxiety follows. Minutes can pass while the heat builds, leaving you wondering what’s happening - and when it will finally stop.

For many women, this isn’t something that starts “later in life.” Hormonal shifts happen throughout adulthood, and for some women, they can begin triggering hot flashes and chills as early as their mid‑30s.

This loss of control is often the hardest part.

A QUICK EXPLANATION (NO MEDICAL JARGON)

Why Hot Flashes and Chills Happen

Your body has a built‑in temperature control system designed to keep you comfortable.

During certain hormonal shifts, that system becomes overly sensitive. Small internal changes can trigger a powerful heat response - even when nothing around you has changed.

When this happens:

  • Your body releases heat rapidly
  • Blood vessels dilate
  • Heart rate increases
  • A rush of heat, sweating, or chills follows

This reaction can also trigger anxiety, especially when it happens unexpectedly.

Your body isn’t broken. Your thermostat is just misfiring.

Chills Can Follow — Or Appear on Their Own

Not all hormonal heat swings run hot.

After a heat surge, the body can overcorrect in the opposite direction. Blood vessels constrict too quickly, pulling warmth away from the skin.

That’s when chills hit.

  • Sudden cold waves
  • Shivering under blankets
  • Feeling unable to warm up despite the room temperature

These swings between hot flashes and chills leave many women feeling anxious, exhausted, and unsure how to respond.

Solution

Palm Cooling Helps Interrupt a Hot Flash

Palm cooling and warming have been clinically studied and applied in medical and physiological settings since the 1970s.

Women who use Cryo‑1 the moment a hot flash starts to help cool down, slow the surge, and feel relief faster. The skin on your palms has one less layer than the rest of your body. That makes them exceptionally good at transferring heat.

When you apply controlled palm cooling or warming:

  • Heat can be removed from the blood during a hot flash
  • Gentle warmth can restore circulation during chills
  • The nervous system begins to settle

The result is faster relief & better temperature regulation.

Why Palm Cooling Works

You don’t need to understand the science to use Cryo‑1. But if you’re curious, here is the science.
Menopause Narrows the Thermal Comfort Zone
Menopause Narrows the Thermal Comfort Zone
Freedman (2001)

Physiological studies suggest palm cooling works by widening the narrowed “thermoneutral zone” caused by low estrogen, allowing excess heat to offload through the palms.

The hypothalamus, which regulates body temperature, becomes oversensitive in menopause, so even small rises in core temperature can trigger a hot flash.

Research by Freedman and colleagues has shown that postmenopausal women have a much narrower thermoneutral zone, meaning very slight changes in core temperature can set off this hypothalamic response

Read the study
Stanford palm cooling technology for performance and hot flash relief
Palm Cooling Stabilizes the Body’s Thermostat
Freedman (2005)

Laboratory research outside of Freedman’s early studies shows that the hypothalamus acts like a thermostat that can become unstable in menopause, causing sudden bursts of heat release.

Palm cooling removes heat directly from the bloodstream, helping to stabilize this thermostat. As a result, women experience fewer episodes of rapid overheating and the uncomfortable waves of sweating that follow

Read the study
Clinical Trial Confirms Palm Cooling Relief
Clinical Trial Confirms Palm Cooling Relief
Reid et al., (2015)

A 2015 study tested a handheld cooling device (Menopod®) applied to the neck for hot flash relief. Results showed limited effectiveness, highlighting that surface cooling on non AVA rich skin alone doesn’t meaningfully lower core temperature.

Still, it supported the link between reduced core temperature and fewer or milder flashes. Cryo-1 applies this same proven principle but uses palm cooling — the Stanford-validated method that directly cools the blood and rapidly stabilizes core temperature.

In Cryomedics’ own user trials, 100% of women reported noticeable relief, with most feeling cooler within 60 seconds.

Read the study
Peripheral Warming Relieves Menopausal Chills
Peripheral Warming Relieves Menopausal Chills
Gombert-Labedens et al. (2025 Review)

Early human and physiology data show that during menopause, drops in estrogen heighten sensitivity to cold and trigger chills. Though direct trials of warming interventions are still emerging, this review notes that warming peripheral skin - especially areas rich in AVAs (arteriovenous anastomoses) like the palms - can help restore thermal comfort by improving circulation and reducing cold sensations. Many women reported relief from cold sweats and shivering when warming strategies were used.

Read the study
Listen to an expert

The Palm Cooling Advantage Explained

Here's neuroscientist Andrew Huberman breaking down why palm cooling works at a physiological level and the extraordinary results it offers.

If you want the science, straight from the lab, hit the play button.

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