Stanford palm cooling technology for performance and hot flash relief

Take Control of Hot Flashes.

Science-backed palm cooling is designed to calm sudden heat spikes and restore comfort — without hormones.

Watch How It Works

Taming the 'Hot-Flash'

You can calm a hot flash quickly, without hormones or medication. It may sound too simple, but the physiology is real.

Cryo-1 is designed to help stabilize sudden heat spikes by safely removing excess heat from your body core. It provides:

  • Fast relief when a hot flash begins
  • Less intense heat surges
  • Improved comfort at night
  • Reduced anxiety around unpredictable symptoms

Some women in our test group experienced significant reduction in their hot flash symptoms with events dropping from an experienced 10 minutes to around 60 seconds when using Cryo-1.

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the problem

Hot Flashes Start Long Before Menopause

Hot flashes don’t suddenly appear at menopause.

For many women, they begin during perimenopause — a transition phase that can last 10 years or more before menopause officially occurs. This phase often starts in a woman’s late 30s or 40s, and it’s far more common than most people realize.

Here’s what’s happening in simple terms:

  • Estrogen levels rise and fall unpredictably
  • The brain’s thermostat (the hypothalamus) becomes overly reactive
  • Blood vessels suddenly open, sending heat to the skin. Heart rate increases. Sweating starts.

The result is a hot flash that feels sudden, intense, and disruptive — even though nothing external has changed.

Despite affecting millions of women, perimenopause is rarely discussed openly. That silence leaves many women feeling unprepared, confused, or dismissed when symptoms begin.

the problem

Hormonal Chills Are Also A Thing

Not all temperature symptoms during perimenopause feel hot.

Many women experience sudden chills, cold waves, or shivering — sometimes immediately after a hot flash, sometimes on their own. These chills can feel confusing and even alarming, especially when the room temperature hasn’t changed.

Here’s why this happens:

  • The same fluctuating estrogen levels disrupt the brain’s thermostat
  • After a heat surge, the body can overcorrect in the opposite direction
  • Blood vessels constrict too quickly, pulling warmth away from the skin

The result is a sudden feeling of being cold, shaky, or unable to warm up — even under blankets.

The SCience

Why Palm Cooling & Warming Works

Our palms are one of the body’s fastest heat‑exchange zones.

Specialized blood vessels called arteriovenous anastomoses (AVAs) allow heat to move rapidly from circulating blood to the outside world.

When the palms are cooled:

  • Heat is pulled directly from the bloodstream
  • Core temperature begins to drop
  • The body’s overactive cooling response starts to settle

When the palms are gently warmed:

  • Blood flow increases at the surface
  • Warmth is returned to the circulation
  • The body’s excessive cooling response begins to normalize

Instead of fighting your body, controlled palm cooling or warming helps it rebalance.

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the solution

Cryo‑1

Cryo-1 brings controlled, science-backed palm cooling & warming into a compact, easy-to-use device designed for real life.

Unlike ice packs, fans, heating pads or invasive treatments, Cryo-1:

  • Targets the palms at the optimal cooling and warming range
  • Works in 60–90 seconds 
  • Is quiet, discreet and portable
  • Requires no water, ice, or preparation

This isn’t masking symptoms — it’s helping the body regulate its temperature naturally.

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Take Control Over Hot Flashes & Chills

Relief doesn’t have to wait — and you don’t have to suffer in silence. In controlled clinical settings, targeted cooling interventions have demonstrated measurable reductions in core temperature, heart rate, and autonomic stress responses within minutes